Martha Plimpton, Tom Bergeron, Sherri Shepherd, David Arquette

The celebrity panel of Martha Plimpton, David Arquette, Tom Bergeron, and Sherri Shepherd is faced with finding out whom the very first guest was on "The Oprah Winfrey Show," a contestant who lost 365 pounds by walking, a contestant who only ate Starbucks for 365 days, someone who can extract venom from snakes, and a professional butt model.